Max Planck Institute for Biochemistry

Placental development and mouse survival requires a specific ubiquitin ligase

Published in Law and Health Weekly, January 22nd, 2005

According to recent research from Germany published in the journal Molecular and Cellular Biology, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network is required for normal placenta development and mouse survival.

"BRUCE is a highly conserved 528kDa peripheral membrane protein of the trans-Golgi network. Owing to the presence of an N-terminal single baculovirus inhibitor repeat, BRUCE functions as an inhibitor of apoptosis protein and blocks apoptosis when overexpressed.

"In addition," wrote K. Lotz and colleagues of the Max Planck Institute for Biochemistry, "due to the presence of a C-terminal...

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Source: Law and Health Weekly (2005-01-22)

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