Dana Farber Cancer Institute, Boston
Partial CD8+ T-cell depletion of PBMC ASCT insufficient to prevent GVHD
Published in Law and Health Weekly, February 12th, 2005
According to a study from the United States, "Prior studies suggest that depletion of CD8+ T cells from donor bone marrow or donor lymphocyte infusions can reduce graft-vs.-host disease (GVHD) without compromising graft-vs.-leukemia.
"We explored CD8 depletion in patients undergoing matched related donor (MRD, n=25) and unrelated donor (URD, n=16) peripheral blood stem cell transplantation following myeloablative conditioning with cyclophosphamide (60 mg/kg/day intravenously x 2) and total body irradiation (200 cGy x 7...
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