Oxidized mitochondrial proteins identified in alcohol-exposed cells

"Heavy alcohol consumption can damage various cells and organs, partly through production of reactive oxygen species (ROS) and mitochondrial dysfunction," scientists in the United States explained. "Treatment with antioxidants can significantly reduce the degree of damage."

"Despite well-established roles of ROS in alcohol-induced cell injury, the proteins that are selectively oxidized by ROS are poorly characterized," noted S.K. Suh and colleagues at the National Institute on Alcohol Abuse and Alcoholism. "We hypothesized that certain cysteinyl residues of target...

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