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Edward Jenner Institute for Vaccine Research

Determinants of HIV escape from primary cytotoxic T cell response

Published in Law and Health Weekly, February 19th, 2005

Researchers examine the determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response in a recent issue of the Journal of Experimental Medicine.

"CD8+ cytotoxic T lymphocytes (CTLs) play an important role in containment of virus replication in primary human immunodeficiency virus (HIV) infection. HIV's ability to mutate to escape from CTL pressure is increasingly recognized; but comprehensive studies of escape from the CD8 T cell response in primary HIV infection are currently lacking. Here, we have fully characterized the primary CTL response to autologous virus Env, Gag, and Tat proteins in three patients, and...

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