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Emory University

Surface stability and immunogenicity of HIV envelope glycoprotein explored

Published in Law and Health Weekly, February 19th, 2005

Researchers report the role of the cytoplasmic domain in the surface stability and immunogenicity of the human immunodeficiency virus envelope glycoprotein.

According to recent research published in the Journal of Virology, "The effects of two functional domains, the membrane-proximal YXXPhi motif and the membrane-distal inhibitory sequence in the long cytoplasmic tail of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env), on immunogenicity of the envelope protein were investigated. Genes with codons optimized for mammalian expression were synthesized for the HIV 89.6 Env and a truncated Env with 50 amino acids in the cytoplasmic domain to...

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