Fraunhofer Institute, Hannover
Mutations in diseased cardiac tissue may have somatic origin
Published in Law and Health Weekly, February 19th, 2005
According to scientists in Germany, "Heart development is complex and requires the sequential and timely interplay of regulatory master proteins, notably several transcription factors. Germline mutations in the human transcription factor genes such as NKX2-5, TBX5 and GATA4 are associated with cardiac anomalies. Familial cases so far studied have different mutations and no mutation can be associated with a specific clinical phenotype. Many cases of CHD come from unaffected family members."
S.M. Reamon-Buettner and colleagues of the Fraunhofer...
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