Nippon Veterinary & Animal Science University

Transcriptional regulation of dectin-2 promoter investigated

Published in Law and Health Weekly, March 12th, 2005

Scientists have investigated transcriptional regulation of dectin-2 promoter in transgenic mice.

According to recent research published in the Journal of Veterinary Medical Science, "Despite a preeminent role of epidermal Langerhans cells (LC) in inducing primary immunity, application of gene-based modification to LC function is limited by lack of well-defined transcription regulatory units that can direct LC-specific gene expression. Previously we reported that the promoter activity of a 5'-flanking region of the dectin-2 gene (Dec2FR) is highly targeted to epidermal LC of transgenic mice bearing a Dec2FR-driven Luc gene. Using the mice, in which transcription...

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Source: Law and Health Weekly (2005-03-12)

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