Max Planck Institute, Gottingen

Alpha-synuclein studied, influence of C-terminal domain on aggregation revealed

Published in Law and Health Weekly, March 12th, 2005

Researchers from Germany have reported on the impact of the acidic C-terminal region on alpha-synuclein aggregation.

"The aggregation of cc-synuclein, involved in the pathogenesis of several neurodegenerative disorders such as Parkinson disease, is enhanced in vitro by biogenic polyamines binding to the highly charged C-terminal region aa109-140," wrote W. Hoyer and colleagues, Max Planck Institute.

"In this study, we investigated the influence of this region on the aggregation kinetics, monitored by thioflavin T binding and static light scattering, and morphology, assessed by electron microscopy, fluorescence microscopy, and turbidity, by comparing...

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Source: Law and Health Weekly (2005-03-12)

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