Harvard University

Peptide:N-glycanase glycoprotein turnover probed

Published in Law and Health Weekly, March 26th, 2005

A study from the United States has documented the use of a small molecule inhibitor of peptide:N-glycanase (PNGase) to probe its role in glycoprotein turnover.

"PNGase is ostensibly the sole enzyme responsible for deglycosylation of unfolded N-linked glycoproteins dislocated from the endoplasmic reticulum (ER) to the cytosol. Here we show the pan-caspase inhibitor, Z-VAD-fmk, to be an active site-directed irreversible inhibitor of yeast and mammalian PNGase at concentrations below those used to inhibit caspases in vivo," wrote S. Misaghi and colleagues, Harvard University.

"Through chemical synthesis we determined that the P-1 residue, electrophile...

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Source: Law and Health Weekly (2005-03-26)

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