Published in Law and Health Weekly, March 26th, 2005
"PNGase is ostensibly the sole enzyme responsible for deglycosylation of unfolded N-linked glycoproteins dislocated from the endoplasmic reticulum (ER) to the cytosol. Here we show the pan-caspase inhibitor, Z-VAD-fmk, to be an active site-directed irreversible inhibitor of yeast and mammalian PNGase at concentrations below those used to inhibit caspases in vivo," wrote S. Misaghi and colleagues, Harvard University.
"Through chemical synthesis we determined that the P-1 residue, electrophile...
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