Emory University

Modified HIV envelope proteins exhibit enhanced binding to antibodies

Published in Law and Health Weekly, March 26th, 2005

Modified HIV envelope proteins exhibit enhanced binding to neutralizing monoclonal antibodies.

According to recent research published in the journal Virology, "The target for neutralizing antibodies against human immunodeficiency virus (HIV) is the trimeric Env protein on the native virion. Conserved neutralizing epitopes of receptor binding sites are located in the recessed core of the Env protein, partially masked by glycosylations and variable loops. In this study, we have investigated the effects of modifications of the HIV Env protein by glycosylation site mutations, deletions of variable loops, or combinations of both types of mutations on their protein...

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Source: Law and Health Weekly (2005-03-26)

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