University of Cologne
Invasive melanoma cells induce metalloproteinase synthesis in fibroblasts
Published in Law and Health Weekly, April 30th, 2005
According to a study from Germany, "Tumor invasion and metastasis of melanoma have been shown to require proteolytic degradation of the extracellular environment, achieved primarily by enzymes of the matrix metalloproteinases (MMP) family. Increased enzyme activity is localized at the border of tumor cells and the adjacent peritumoral connective tissue, emphasizing the crucial role of tumor-stroma interactions in the regulation of MMP activity. To analyze whether direct cell-cell contacts of melanoma cells...
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