Max Delbruck Center for Molecular Medicine, Berlin
Findings in oncology provide new insights
Published in Law and Health Weekly, April 30th, 2005
Study 1: Gene networks reverse breast cancer tumorigenesis after chromosome 8 delivery.
"Several investigations have supposed that tumor suppressor genes might be located on human chromosome 8. We used microcell-mediated transfer of chromosome 8 into MDA-MB-231 breast cancer cells and generated independent hybrids with strongly reduced tumorigenic potential. Loss of the transferred chromosome results in reappearance of the malignant phenotype," scientists writing in the journal Oncogene report.
"Expression analysis identified a set of 109 genes...
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