Tohoku University
Alzheimer amyloid beta precursor studied, alpha-secretase cleavage shown
Published in Law and Health Weekly, April 30th, 2005
"In the processing of APP, alpha- and P-secretase pathways compete with each other for cleaving APP. Therefore, physiologically these two secretases are likely to colocalize in the same subcellular compartments.
"Previously beta-secretase cleavage of APP was found in the endoplasmic reticulum (ER). We herein tested whether alpha-secretase cleavage is also detected in the ER," wrote R.W. Shin and colleagues, Tohoku University.
"We used experimental system of COS7 cells transfected...
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