Charles University

Stereoselectivity of sibutramine in hepatocytes reported

Published in Law and Health Weekly, May 28th, 2005

Researchers report the stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes in a recent issue of the Journal of Pharmacy and Pharmacology.

According to a study from the Czech Republic, "Sibutramine is an anti-obesity drug sold as a racemic mixture under the trademark Meridia or Reductil. With the aim of evaluating the stereoselectivity in phase I of sibutramine biotransformation, the formation of the main metabolites from R-sibutramine, S-sibutramine and rac-sibutramine was studied in rat microsomes and primary cultures of hepatocytes. A novel analytical method for the...

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Source: Law and Health Weekly (2005-05-28)

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