Montefiore Medical Center

Heat shock protein 70 examined, role in clonogenicity of leukemic cells revealed

Published in Law and Health Weekly, May 28th, 2005

Recently published research from the United States has described the clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70 (Hsp70).

"Pretreatment of human leukemia THP-1 cells with Hsp70 protected them from the cell-lethal effects of the topoisomerase II inhibitor, lucanthone and from ionizing radiation," wrote R. Bases and colleagues, Montefiore Medical Center.

"Cell viability was scored in clonogenic assays of single cells grown in liquid medium containing 0.5% methyl cellulose. Colonies were observed and rapidly scored after staining with the tetrazolium salt, 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl...

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Source: Law and Health Weekly (2005-05-28)

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