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National Cardiovascular Center, Osaka

Study investigated negative chronotropic response to low-dose atropine

Published in Law and Health Weekly, June 4th, 2005

Negative chronotropic response to low-dose atropine is associated with parasympathetic nerve-mediated cardiovascular response in postoperative patients with congenital heart disease.

In a recent report published in the International Journal of Cardiology, researchers in Japan conducted a study "to investigate the negative chronotropic response (NCR) to low-dose atropine in postoperative patients with congenital heart disease (CHD). Low-dose atropine causes a NCR through the central nervous system muscarinic receptor and is attenuated in adult heart failure patients. It has never been evaluated in CHD patients."

H. Ohuchi and colleagues of the...

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