Sumitomo Pharmaceutical Co. Ltd, Osaka
Na+/Ca2+ inhibitors may have therapeutic potential
Published in Law and Health Weekly, July 30th, 2005
According to recent research from Japan, "synthesis, and structure-activity relationships of 3,4-dihydro-2(l H)-quinazolinone derivatives as inhibitors of the sodium/calcium (Na+/Ca2+) exchanger are discussed. These studies, based on a lead compound 9a, which was identified in our library, involved systematic modification of three regions and revealed that the 3,4-dihydro-2(1H)-quinazolinone having a tertiary amino alkyl side chain at the 3-position is essential for activity, a nonsubstituted phenyl ring is most suitable for high activity, and...
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