University of Chicago
Findings advance knowledge in diabetes pathogenesis research
Published in Law and Health Weekly, July 30th, 2005
Study 1: The foldability and function of insulin are inversely regulated by a stereospecific switch in the B chain.
According to recent research published in the journal Biochemistry, "how insulin binds to its receptor is unknown despite decades of investigation. Here, we employ chiral mutagenesis - comparison of corresponding D and L amino acid substitutions in the hormone - to define a structural switch between folding-competent and active conformations. Our strategy is motivated by the T -> R transition, an allosteric feature of...
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