Chiron Corporation
Prime-boost regimen enhances potency of DNA HIV vaccines
Published in Law and Health Weekly, August 20th, 2005
"DNA vaccines have been used widely in experimental primate models of human immunodeficiency virus (HIV), but their effectiveness has been limited. In this study, we evaluated three technologies for increasing the potency of DNA vaccines in rhesus macaques. These included DNA encoding Sindbis virus RNA replicons (pSINCP), cationic poly(lactide-co-glycolide) (PLG) microparticles for DNA delivery, and recombinant protein boosting," researchers in the United States report.
"The DNA-based pSINCP...
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