University of Hohenheim, Stuttgart
TGF-beta 1 tightly regulates intestinal mast cell growth/phenotype/function
Published in Law and Health Weekly, August 27th, 2005
"Transforming growth factor beta 1 (TGF-beta 1) is expressed in the healthy human intestine and controls mucosal immune responses and inflammation by regulating the function of lymphocytes, macrophages, dendritic cells, and eosinophils.
"Here, we asked whether human intestinal mast cells (MC) might also be subject to immunoregulation by TGF-beta 1," wrote investigators in Canada.
"MCs were isolated from the intestinal mucosa, purified, and cultured in vitro in the presence of stem cell factor (SCF) with or without TGF-beta...
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