University of Manchester
CD105 erases the effects of transforming growth factor on vessel growth
Published in Law and Health Weekly, August 27th, 2005
According to recent research from England, "angiogenesis is important in health and several disease states. CD105 is a proliferation-associated and hypoxia-inducible transmembrane protein abundantly expressed in angiogenic endothelial cells."
"CD105 is a receptor for transforming growth factors beta 1 (TGF)-beta1 and -beta3 . The exact mechanisms for CD105 regulation of vascular development have not been fully elucidated. In this study, an antisense approach to create a murine and a human stably transfected endothelial cell line expressing a reduction in...
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