Oregon Health and Science University
Leptin and melanocortin play roles in signaling in cachexia
Published in Law and Health Weekly, September 24th, 2005
According to a study from the United States, " The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R). We performed either subtotal nephrectomy (N) or sham operations in WT, leptin receptor-deficient (db/db), and MC4-R knockout (MC4-RKO) mice. The animals were on 17% protein diets, and none of the uremic animals were acidotic."
"WT-N mice produced a classic syndrome of cachexia characterized by decreased food intake,...
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