Cleveland Clinic
Heterogeneous alterations in alloimmunity linked to immunization
Published in Law and Health Weekly, October 8th, 2005
According to a study from the United States, "The presence of alloantibodies and/or alloreactive T cells in a patient prior to a transplant can impact graft outcome. Environmental factors, including therapeutic vaccinations, may influence the strength and/or specificity of alloimmunity. To address this issue, we prospectively evaluated the effects of two different immunization protocols in human subjects on cellular alloimmunity using an IFN-gamma ELISPOT assay and on alloantibody reactivity by flow cytometric analysis...
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