Biomedical Primate Research Center, Rijswijk
Alternate priming approaches enhance hepatitis C vaccine in rhesus macaques
Published in Law and Health Weekly, October 8th, 2005
"Preventive and therapeutic vaccine strategies aimed at controlling hepatitis C virus (HCV) infection should mimic the immune responses observed in patients who control or clear HCV, specifically T helper (Th) type 1 and CD8+ cell responses to multiple antigens, including nonstructural protein (NS) 3. Given the experience with human immunodeficiency virus, the best candidates for this are based on DNA prime, pox, or adenovirus boost regimens," researchers in the Netherlands report.
"In rhesus macaques, we compared NS3-expressing DNA prime and adenovirus boost strategy with...
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