M.D. Anderson Cancer Center

Alternating triple chemotherapy achieves better MR rates than central lymphatic irradiation

Published in Law and Health Weekly, October 29th, 2005

Intensive alternating triple chemotherapy (ATT) achieves better molecular response (MR) rates than central lymphatic irradiation (CLI).

"This study was undertaken to compare the MR rates of 2 regimens, CLI and ATT, in the treatment of Stage I-III follicular lymphoma. MR was defined as disappearance of t(14;18) (q32;q21) amplified by polymerase chain reaction (PCR). Sixty-five patients with Stage I to III follicular lymphoma were randomized," scientists in the United States reported.

"CLI consisted of the mantle, abdomen, and pelvic radiation fields. ATT alternated among CHOD-Bleo, ESHAP, and NOPP for 12 courses. Bone marrow (BM) and peripheral blood...

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Source: Law and Health Weekly (2005-10-29)

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