Published in Law and Health Weekly, October 29th, 2005
"A rapid and specific HPLC method has been developed and validated for simultaneous determination of clobazam, the anticonvulsant agent, and its major metabolite in human plasma. The sample preparation was a liquid-liquid extraction with toluene yielding almost near 100% recoveries of two compounds," scientists in Iran report.
"Chromatographic separation was achieved with a Chromolith Performance RP-18e 100 mmx4.6 mm column, using a mixture of a phosphate buffer (pH 3.5; 10mM)-acetonitrile (70:30, v/v), in isocratic mode at 2ml/min at a detection wave-length of...
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