University of Illinois

The heparin-binding site of antithrombin is critical for blocking angiogenesis

Published in Law and Health Weekly, October 29th, 2005

The heparin-binding site of antithrombin is critical for blocking angiogenesis.

"The heparin-binding site of antithrombin is shown here to play a crucial role in mediating the antiangiogenic activity of conformationally altered cleaved and latent forms of the serpin," investigators in the United States report.

"Blocking the heparin-binding site of cleaved or latent antithrombin by complexation with a high-affinity heparin pentasaccharide abolished the serpin's ability to inhibit proliferation, migration, capillary-like tube formation, basic fibroblast growth factor (bFGF) signaling, and perlecan gene expression in bFGF-stimulated human umbilical vein...

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Source: Law and Health Weekly (2005-10-29)

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