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University of Bologna

Poly(vinyl alcohol)-co-oleylvinyl ether derivative elicits cytotoxic response in tumor

Published in Law and Health Weekly, November 12th, 2005

Poly(vinyl alcohol)-co-oleylvinyl ether derivative elicits cytotoxic response in tumor cells.

"A series of poly(vinyl alcohol) amphiphilic derivatives have been prepared to obtain polymeric aggregates in aqueous phase holding thermodynamic instability. The aim was to evaluate their ability to interact with tumor cells eliciting selective cytotoxicity," scientists writing in the journal Biomacromolecules report.

"The poly(vinyl alcohol) derivatives were prepared by partial substitution of poly(vinyl alcohol) (MW 10 kDa) with both oleyl chains and poly(ethylene glycol) monoethyl ethers (PEGMEE) of different molecular weights. The substitution...

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