University of Roma La Sapienza
Immune escape may offer hepatitis C virus variants a survival advantage
Published in Law and Health Weekly, November 19th, 2005
According to recent research from Italy, "cellular immune responses are induced during HCV infection and acute-phase CD8+ T cells are supposed to play an important role in controlling viral replication. In chimpanzees, failure of CD8+ T cells to control HCV replication has been associated with acquisition of mutations in MHC class I-restricted epitopes."
"In humans, although selection of escape mutations in an immunodominant CTL epitope has been recently described, the overall impact of immune escape during acute HCV infection is unclear," wrote S. Guglietta and...
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