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University of Paris 07

HIV-1 variants from single plasma samples have various neutralization sensitivities

Published in Law and Health Weekly, November 19th, 2005

HIV-1 variants from single plasma samples have various neutralization sensitivities.

According to recent research from France, "Individuals infected with human immunodeficiency virus type 1 (HIV-1) harbor a mixture of viral variants with different sequences and in some instances with different phenotypic properties.

"Major and rapid fluctuations in the proportion of viral variants coexisting in an infected individual can be observed under strong pharmacological and immune selective pressure."

"Because of the short half-life of HIV-infected cells and of HIV virions in the blood, plasma virus populations are highly relevant to HIV...

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