Istituto Superiore di Sanita, Rome
Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of acute myeloid leukemia
Published in Law and Health Weekly, November 26th, 2005
According to recent research published in the journal Blood, "Leukemic blasts from patients with AML frequently express high levels of the interleukin-3 receptor of chain (IL-3R alpha). In the present study, we have explored the sensitivity of primary leukemic blasts obtained from 34 patients with AML to a diphtheria toxin (DT) composed of the catalytic and translocation domains of DT388IL-3 and to DT388 fused to a variant IL-3 with increased binding affinity (DT388IL-3[K116W])."
"On a molar basis, DT388IL-3[K116W] was...
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