Harvard University
HLA class II alleles associated with HIV-1 pathogenesis in Botswana
Published in Law and Health Weekly, November 26th, 2005
"Southern Africa is facing an unprecedented public health crisis due to the high prevalence of human immunodeficiency virus type 1 (HIV-1). Vaccine development and testing efforts, mainly based on elicitation of HIV-specific T cells, are under way.
"To understand the role of human leukocyte antigen (HLA) class II alleles in HIV pathogenesis and to facilitate HLA-based HIV-1 vaccine design, we analyzed the frequencies of HLA class II alleles within the southern African country of Botswana," investigators in the United States report.
"Common HLA class II...
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