Academy of Sciences of the Czech Republic, Prague
DNA vaccines based on chimeric potyvirus-like particles carrying HPV16 E7 peptide developed
Published in Law and Health Weekly, December 3rd, 2005
According to recent research from the Czech Republic, "Vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 E7 (HPV16 E7) oncoprotein. The immunogenicity of the E7 gene has been enhanced by its fusion to many different genes."
"Here, we linked a short sequence coding for the E7 peptide (aa 44-60) containing immunodominant epitopes for B and T cells to the 3' end of the gene coding for the whole coat protein (CP) of the potyvirus, potato virus A (PVA), and its...
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