University of Milan

Hepatitis C virus antigens can be expressed in Saccharomyces cerevisiae

Published in Law and Health Weekly, December 17th, 2005

Recent research from Italy has described the heterologous production of five hepatitis C virus (HCV)-derived antigens in three Saccharomyces cerevisiae host strains.

"In this study," wrote C. Parolin and colleagues, University of Milan, "the production of recombinant HCV derived proteins from transformed S. cerevisiae yeast cells is reported.

"Three different yeast strains (GRF18U, BY4743-4A and CENPK 113-5D) have been transformed for the intracellular expression of five antigens of different dimensions (from 32.8 to 85.2 kDa), all derived from the non-structural (NS) region of different HCV viruses' genotypes and posed under the...

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Source: Law and Health Weekly (2005-12-17)

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