Russian Academy of Sciences

Immunization with mucin 1 and its coding DNA had anti-tumor effect

Published in Law and Health Weekly, January 14th, 2006

Double immunization of mice with mucin 1 and its coding DNA had an anti-tumor effect.

Researchers in Russia and the Netherlands conducted a study "to evaluate the antitumor effect of mouse immunization with human mucin 1 gene (muc1) DNA plasmids combined with simultaneous injections of human mucin I (MUC1) protein."

"MUC1 DNA was cloned in pBK-CMV to prepare DNA plasmids and in pET22b+ to produce proteins. Three strains of mice, immunized with DNA or DNA plus MUC1, were inoculated with tumor cells obtained from spontaneous tumors. IgG_2a , production, MUC1-specific IFN-gamma-producing CD8+ T cells, tumor growth and mouse survival were...

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Source: Law and Health Weekly (2006-01-14)

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