Fukuoka University

Monoclonal antibodies for MK-1/Ep-CAM have been prepared

Published in Law and Health Weekly, January 14th, 2006

Scientists have prepared human IgG and IgM monoclonal antibodies for MK-1/Ep-CAM using human immunoglobulin gene-transferred mouse and gene cloning of their variable regions.

According to recent research published in the journal Anticancer Research, "For antibody-based therapy of cancer, monoclonal antibodies (mAbs) of human origin are superior to mouse, mouse/human chimeric or humanized mAbs, because of their minimum immunogenicity to humans and their efficient collaboration with human effector cells. In the present study, human mAbs were prepared against a pancarcinoma antigen, MK-1 (Ep-CAM), using a genetically-engineered mouse (KM mouse (TM)) that contains...

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Source: Law and Health Weekly (2006-01-14)

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