U.S. National Institute for Allergy & Infectious Diseases

Study characterized blood-activated chitinolytic system in sand fly midgut

Published in Law and Health Weekly, January 14th, 2006

In a recent issue of the journal Insect Molecular Biology, researchers characterize a blood-activated chitinolytic system in the midgut of the sand fly vectors Lutzomyia longipalpis and Phlebotomus papatasi.

According to the study report, "We characterized a cDNA from Phlebotomus papatasi, PpChit1, which encodes a midgut specific chitinase and show the presence of a functional, blood-induced chitinolytic system in sand flies. PpChit1 is detected only in the midgut and is regulated by blood feeding."

"A recombinant protein (rPpChit1) produced in HEK 293-F cells exhibited a similar activity profile to that found in the...

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Source: Law and Health Weekly (2006-01-14)

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