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Harvard University

Researchers detail new studies and findings in the area of HIV/AIDS vaccines

Published in Law and Health Weekly, March 18th, 2006

HIV/AIDS vaccines data are the focus of recent research from the United States and France.

Study 1: CD4+ T cells derived from lentiviral-transduced CD34+ hematopoietic cells inhibited simian/human immunodeficiency virus replication.

Investigators in the United States report, "We examined the ability of a HIV-1-based vector (VRX494) encoding a 937-bp antisense HIV-1 envelope sequence to inhibit the replication of chimeric SIV/HIV-1 viruses encoding the HIV-1 envelope. Challenge of VRX494-transduced CEMx174 cells resulted in potent inhibition of HIV-1 and several SHIV strains."

"To evaluate the potential efficacy of the VRX494...

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