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Beijing Union Medical College Hospital
HIV disease progression rate influenced by HLA-B locus polymorphism
April 8th, 2006
The HLA-B locus polymorphism influences the rate of HIV disease progression. According to recent research from the People's Republic of China, "Most HIV-1-infected individuals progress to AIDS within 8 to 10 years after seroconversion. Less than 5% of them, however, remain asymptomatic, although their CD4+ T-cell counts stay normal." "In this study, our polymerase chain reaction sequence-specified primer (PCR-SSP) based human leukocyte antigen (HLA)-B genotyping of 28 typical progressors (TPs) and 15 long-term nonprogressors (LTNPs) revealed some evidence that an HLA-B locus polymorphism can influence the rate of disease progression in Chinese...
Source: Law & Health Weekly (2006-04-08)
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