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John Radcliffe Hospital, Oxford
HIV-1 vaccines were safe in healthy HIV-1-uninfected volunteers
April 8th, 2006
Results from a phase I clinical trial indicated that a DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1 (HIV-1) vaccine administered alone and in a prime-boost regime was safe in healthy HIV-1-uninfected volunteers. "DNA-and modified virus Ankara (MVA)-vectored candidate vaccines expressing human immunodeficiency virus type 1 (HIV-1) clade A-derived p24/p17 gag fused to a string of HLA class I epitopes, called HIVA, were tested in phase I trials in healthy, HIV-1/2-uninfected adults in Oxford, United Kingdom. Eighteen volunteers were vaccinated with pTHr.HIVA DNA (IAVI-001) alone, eight volunteers received MVA.HIVA (IAVI-003) alone and nine...
Source: Law & Health Weekly (2006-04-08)
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