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All India Institute of Medical Science
HBV surface antigen used to generate high-affinity chimeric antibody
April 8th, 2006
Recent research from India has documented the generation of a high-affinity chimeric antibody against hepatitis B surface antigen (HbsAg). "Antibody against HBsAg is advocated for the passive immunotherapy in certain cases of hepatitis B infections. A recombinant monoclonal antibody against HBsAg would offer several advantages over the currently used polyclonal human hepatitis B immunoglobulin. "SS is a mouse monoclonal antibody that binds to HBsAg with very high affinity. However, this mouse antibody cannot be used for therapeutic purposes, as it may elicit anti-mouse immune responses. Chimerization, by replacing mouse constant domains with human...
Source: Law & Health Weekly (2006-04-08)
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