University of Montreal

Basic FGF expression in astrocytes affects dopamine neuron synaptic function and development

Published in Law and Health Weekly, April 15th, 2006

According to a study from Canada, basic FGF expression in astrocytes affects dopamine neuron synaptic function and development.

"Behavioural sensitization to amphetamine (AMPH) requires action of the drug in the ventral midbrain where dopamine (DA) neurons are located. In vivo studies suggest that AMPH sensitization requires enhanced expression of basic fibroblast growth factor (bFGF) in the nucleus of midbrain astrocytes.

"One idea is that the AMPH-induced increase in bFGF expression in astrocytes leads to enhanced secretion of this peptide and to long-term plasticity in DA neurons," wrote C. Forget and colleagues, University of Montreal. "To study...

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Source: Law and Health Weekly (2006-04-15)

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