University of Washington
Hepatitis C virus replication is influenced by CXCL-8 and related mRNA stability
Published in Law and Health Weekly, April 22nd, 2006
"Previous studies have shown that levels of CXCL-8 are elevated in patients with chronic HCV infection and are highest in nonresponders to interferon (IFN) therapy and that CXCL-8 inhibits IFN antiviral action. CXCL-8 expression involves AU-rich elements (AREs) in 3' untranslated regions that regulate mRNA stability.
"CXCL-8 mRNA stability was, therefore, investigated in the context of HCV replication in 4 replicon cell lines, Huh7 and Huh7.5 cells, and primary human fetal hepatocytes," wrote J. Green and...
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