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University of Ulm

Dendritic cells from leukemic blasts were used against acute myeloid leukemia

Published in Law and Health Weekly, May 13th, 2006

Autologous dendritic cells generated from leukemic blasts show promise as immunotherapy for patients with acute myeloid leukemia.

Scientists writing in the International Journal of Oncology report, "Vaccination with dendritic cells (DCs) as professional antigen presenting cells generated from autologous leukemic blasts might elicit anti-leukemic T cell responses in patients with acute myeloid leukemia (AML). To test this hypothesis, autologous AML-DC were generated under good manufacturing practice (GMP) conditions and injected s.c. into five AML patients up to four times at a biweekly interval."

"No severe adverse side effects were observed,"...

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