Columbia University, New York
Cyclophilin A and TRIM5 alpha independently regulate HIV infectivity
Published in Law and Health Weekly, May 13th, 2006
"Cyclophilin A (CypA), a cytoplasmic, human immunodeficiency virus type 1 (HIV-1) CA-binding protein, acts after virion membrane fusion with human cells to increase HIV-1 infectivity. HIV-1 CA is similarly greeted by CypA soon after entry into rhesus macaque or African green monkey cells, where, paradoxically, the interaction decreases HIV-1 infectivity by facilitating TRIM5 alpha-mediated restriction. These observations conjure a model in which CA recognition by the human TRIM5 alpha orthologue is precluded by CypA," noted scientists in the United...
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