University of California, San Diego
Angiogenesis may be triggered by low density lipoprotein receptor-related protein-1
Published in Law and Health Weekly, May 13th, 2006
"LRP-1 is a catabolic receptor for extracellular matrix (ECM) structural proteins and for proteins that bind to ECM. LRP-1 also is implicated in integrin maturation," investigators in the United States report.
"In this study, we applied a proteomics strategy to identify novel proteins involved in ECM modeling that are regulated by LRP-1. We show that LRP-1 deficiency in murine embryonic fibroblasts (MEFs) is associated with increased levels of type III collagen and pigment epithelium-derived factor, which accumulate in the substratum surrounding cells," said...
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