University of California, San Diego

HSP72 surface expression facilitates gamma delta T cell-mediated killing

Published in Law and Health Weekly, May 27th, 2006

According to recent research from the United States, surface expression of heat shock protein 72 (HSP72) by lipopolysaccharide (LPS)-stimulated neutrophils facilitates gamma delta T cell-mediated killing.

"During inflammation and sepsis, accumulation of activated neutrophils causes lung tissue damage and organ failure. Effective clearance of neutrophils reduces the risk of organ failure; however, its mechanisms are poorly understood.

"Because lungs are rich in gamma delta T cells, we investigated the physiological role of these cells in the protection of lung tissue from infiltrating neutrophils," wrote M.I. Hirsh and colleagues, University of...

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Source: Law and Health Weekly (2006-05-27)

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