Centre Hospitalier de l'Universite de Clermont Ferrand
Analgesic action of acetaminophen might involve serotonergic system
Published in Law and Health Weekly, June 10th, 2006
According to recent research from France, "Preclinical studies have suggested that the mechanism of the analgesic action of acetaminophen (INN, paracetamol) is linked to the serotonergic system and that it is inhibited by tropisetron, a 5-hydroxy-wtryptamine type 3 antagonist. The aim of this study was to confirm these findings in humans."
"Twenty-six rapid metabolizers of tropisetron were included in this double-blind crossover study," explained G. Pickering and colleagues, Centre Hospitalier de l'Universite de Clermont Ferrand. "After ethical approval, at weekly intervals,...
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