Dr. Daniel Den Hoed Cancer Center, Rotterdam
Phoenix clone effectively transduces human T cells with tumor-specific receptors
Published in Law and Health Weekly, June 10th, 2006
"We have designed a transgene that encodes a scFv(G250) chimeric receptor, which is specific for carboxyanhydrase IX (G250-ligand, G250L), a molecule overexpressed by renal cell cancer (RCC). Retroviral transduction of this transgene into primary human T lymphocytes confers these cells with specific functional responses towards G250L-positive RCC cells," wrote C.H.J. Lamers and colleagues, Dr. Daniel Den Hoed Cancer Center.
"In preparation of a clinical phase (I/II) study in RCC patients, we...
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