City of Hope National Medical Center, Duarte
RNAi is developed as treatment for HIV-1 infection
Published in Law and Health Weekly, June 24th, 2006
According to a review from the United States, "Human immunodeficiency virus type 1 (HIV-1) was the first primate virus shown to he inhibited by RNA interference (RNAi). Early studies used both synthetic and promoter expressed small interfering RNAs (siRNAs) or expressed short hairpin RNAs (shRNAs) to demonstrate that this virus was susceptible to RNAi. In addition to targeting the virus itself RNAi-mediated down-regulation of cellular targets that encode receptors required for viral entry also proved to be effective."
"The power of RNAi as an anti-HIV agent has propelled development...
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